The hallmarks of cancer are concept of prying system for extensive development for cancer. Cancer metabolism has now become more complicated thus it needs budding clarification for better refinement. Also non-mutational transition and complex system of micro biota both synergistically enables the addition of various hallmarks in cancer development. In addition to this, senescent cells simultaneously act in tumor microenvironment which is important for maintaining functionally ability
[1] Cilloni D, Saglio G: Molecular pathways: BCR-ABL, Clin Cancer Res 18:930–937, 2012
[2] Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57–70
[3] . Hallmarks of Cancer : New Dimensions. Douglas Hanahan. Published January 2022
[4] .CArtandi, S.E., and DePinho, R.A. (2010). Telomeres and telomerase in cancer. Carcinogenesis 31, 9–18
[5] Biological hallmarks of cancer Biological hallmarks of cancer Biological hallmarks of cancer Douglas Hanahan, PhD ■ Robert A. Weinberg, PhD
[6] Weinberg RA. The Biology of Cancer. New York: Garland Press; 2013
[7] Lemmon, M.A., and Schlessinger, J. (2010). Cell signaling by receptor tyrosine kinases. Cell 141, 1117–113
[8] Burkhart, D.L., and Sage, J. (2008). Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat. Rev
[9] Burkhart, D.L., and Sage, J. (2008). Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat. Rev
[10].e, B.K., Lallemand, D., Liu, C.H., and McClatchey, A.I. (2007). Contactdependent inhibition of EGFR signaling by Nf2/Merlin. J. Cell Biol. 177, 893–903
[11]Partanen, J.I., Nieminen, A.I., and Klefstrom, J. (2009). 3D view to tumor suppression: Lkb1, polarity and the arrest of oncogenic c-Myc. Cell Cycle 8, 716–724. .
[12].Ikushima, H., and Miyazono, K. (2010). TGFbeta signalling: a complex web in cancer progression. Nat. Rev. Cancer 10, 415–424
[13]Adams, J.M., and Cory, S. (2007). The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 26, 132
[14] Willis, S.N., and Adams, J.M. (2005). Life in the balance: how BH3-only proteins induce apoptosis. Curr. Opin. Cell Biol. 17, 617–625.
[15]Levine, B., and Kroemer, G. (2008). Autophagy in the pathogenesis of disease. Cell 132, 27–42
[16] White, E., and DiPaola, R.S. (2009). The double-edged sword of autophagy modulation in cancer. Clin. Cancer Res. 15, 5308–5316
[17] Amaravadi, R.K., and Thompson, C.B. (2007). The roles of therapy-induced autophagy and necrosis in cancer treatment. Clin. Cancer Res. 13, 7271–7279.
[18] Apel, A., Zentgraf, H., Bu¨ chler, M.W., and Herr, I. (2009). Autophagy-A doubleedged sword in oncology. Int. J. Cancer 125, 991–995.
[19]Galluzzi, L., and Kroemer, G. (2008). Necroptosis: a specialized pathway of programmed necrosis. Cell 135, 1161–1163
[20] Grivennikov, S.I., Greten, F.R., and Karin, M. (2010). Immunity, inflammation, and cancer. Cell 140, 883–899.
