Heterogenous group of incapacitating disorders affecting the cutaneous regions constitutes the genodermatoses. Oral Genodermatous conditions are inbred cutaneous disorderliness unveiling oral expressions. Tongue, palate, gingiva, salivary gland and alveolar dentition represents the common site. The specializing factor is that at times it might be the starring sign of this condition. Lack of awareness about this condition results in extensive dilemma to treat this condition. The current management criteria are also fictional for this particular disorders. Novel approach consists of repurposing drugs, and have been examined for other pathologies. Nevertheless, recent expertise stays furthermore contributing novel innovative gears, which aids to interpose the etiology of genodermatoses besides therefore both refurbish the unnatural gene or genomic artefact. The aim of dental intervention is to re-establish dental health. Further limiting factors and disputes which includes effective drug delivery and targeted therapy are discussed, emphasized in immunotherapy of genodermatosis.

• Mucocutaneous lesions,
• Gene mutations
• Immunotherapy

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