The oral and systemic health have a bidirectional relationship that has been studied by many authors. Development of non-invasive diagnostic techniques to overcome the limitations of conventional diagnostic techniques such as serum analysis has gained much momentum in the recent years. Advances in the "omics" disciplines have led to the discovery of a slew of molecules such as genetic variations, proteins, RNA transcripts, and small metabolites that might aid in the early detection of at-risk persons. Saliva, commonly called the "mirror of the body," appears to be an appealing alternative for laboratory or clinical assessment, therapy monitoring, and prognosis evaluation in both oral and systemic disorders. In recent times the development of the field of molecular diagnostics has propelled salivary diagnostics to advance into a complex science, which is being used in a wide spectrum of biomedical and clinical fields
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