In recent years organic chemist focused on green chemistry for organic synthesis transformations because the silica supported catalyst is more stable, efficient and easy to recover and reusable after reaction. The silica supported copper catalyst is design from E-Waste, It used for formation of benzimidazoles from diamines and aldehydes.it is very deep work done by various catalyst, we noted in our research in unique method develop for synthesis of benzimidazoles made by condensation diamine and aldehydes via silica supported copper nano particles under EtOH as reaction media . The reactions done at 60° C temperature for 80 minute by 1:1.2 ratio mixture of diamine and aldehydes in the presence of nano catalyst to give the desired products with high purity.

• Schame:01 ,

1) For some recent reviews on directed C-H functionalization reactions, see: (a) Colby, D. A.; Bergman, R.G.; Ellman, J. A. Chem. Rev. 2010, 110, 624. (b) Wencel-Delord, J.; Droge, T.; Liu, F.; Glorius, F. Chem.Soc. Rev. 2011, 40, 4740. (c) Wendlandt, A. E.; Suess, A. M.; Stahl, S. S. Angew. Chem., Int. Ed. 2011,50, 11062. (d) Engle, K. M.; Mei, T.-S.; Wasa, M.; Yu, J.-Q. Acc. Chem. Res. 2012, 45, 788. (e)

2) Hickman, A. J.; Sanford, M. S. Nature Rev. 2012, 484, 178. (f) Wencel-Delord, J.; Glorius, F. Nature Chem. 2013, 5, 369.

3) Afaf, H.E., Fahmy, H.H., Abdelwal, S.H., 2000. Molecules 5, 1429. Amari, M., Fodili, M., Nedjar-kolli, B., 2002. Reactivity studies on 4- aminopyrones: Access to benzimidazole and benzimidazolone derivatives. J. Heterocycl. Chem. 39, 811

4) Ansari, K.F., Lal, C., 2009a. Synthesis and evaluation of some newbenzimidazole derivatives as potential antimicrobial agents. Eur. J. Med. Chem. 44, 2294.Ansari, K.F., Lal, C., 2009b. Synthesis, physicochemical propertiesand antimicrobial activity of some new benzimidazole derivatives.Eur. J. Med. Chem. 44, 4028.

5) Bansal, R.K., 2002. Herocyclic Chemistry, third ed. Publisher, New Delhi, New Age International, 401 pp. Bishnoi, A., Pandey, V.K., Saxena, R., 1978. Synthesis and characterization of benzimida-zolylphenothiazine derivatives and a study of their antiviral and antifungal activities. Ind. J. Chem. 41B, 1978.

6) Bistrzycki, Ulffers, 1980. Ueber Diacyl-o-Diamine. Ber. 23, 1876.Campbell, W.C., Denham, D.A., 1983. Chemotherapy. In: Campbell, W.C. (Ed.), Trichinilla and Trichinosis. Plenum Press, USA and London, UK, 340 pp.

7) Demirayak, S., Mohsen, U.A., Karaburun, A.C., 2002. Synthesis andanticancer and anti-HIV testing of some pyrazino[1,2-a]benzimidazole derivatives. Eur. J. Med. Chem. 37, 255. Evans, D., Hicks, T.A., Williamson, W.R.N., Meacock, S.C.R., Kitchen, E.A., 1996. Synthesis of a group of 1H–benzimidazoles and their screening for antiinflammatory activity. Eur. J. Med.Chem. 31, 635.

8) Fischer, Veiel., 1905. The chemistry of benzimidazoles. Ber. 38, 320.Gaba, M., Sing, D., Singh, S., Sharma, V., Gaba, P., 2010. Synthesis and pharmacological evaluation of novel 5-substituted-1-(phenylsulfonyl)-2-methylbenzimidazole derivatives as anti-inflammatory and analgesic agents. Eur. J. Med. Chem. 45, 2245

9) Shaharyar, M., & Mazumder, A. (2017). Benzimidazoles: A biologically active compounds. Arabian Journal of Chemistry, 10, S157-S173.

10) Brauer, V. S., Rezende, C. P., Pessoni, A. M., De Paula, R. G., Rangappa, K. S., Nayaka, S. C., ... & Almeida, F. (2019). Antifungal agents in agriculture: Friends and foes of public health. Biomolecules, 9(10), 521.

11) Tahlan, S., Kumar, S., & Narasimhan, B. (2019). Pharmacological significance of heterocyclic 1 H-benzimidazole scaffolds: a review. BMC chemistry, 13(1), 1-21.

12) Kalarani, R., Sankarganesh, M., Kumar, G. V., & Kalanithi, M. (2020). Synthesis, spectral, DFT calculation, sensor, antimicrobial and DNA binding studies of Co (II), Cu (II) and Zn (II) metal complexes with 2-amino benzimidazole Schiff base. Journal of Molecular Structure, 1206, 127725.

13) Wang, S. Q., Wang, Y. F., & Xu, Z. (2019). Tetrazole hybrids and their antifungal activities. European journal of medicinal chemistry, 170, 225-234.

14) Kalarani, R., Sankarganesh, M., Kumar, G. V., & Kalanithi, M. (2020). Synthesis, spectral, DFT calculation, sensor, antimicrobial and DNA binding studies of Co (II), Cu (II) and Zn (II) metal complexes with 2-amino benzimidazole Schiff base. Journal of Molecular Structure, 1206, 127725.

15) Rashid, Mohammad. "Design, synthesis and ADMET prediction of bis-benzimidazole as anticancer agent." Bioorganic chemistry 96 (2020): 103576.

16) Mahida, J., & Patel, R. B. Green Reusable Catalyst For The Formation Diastereo Selective Synthesis Of Cyclohexanones By Condensation Reaction Acetoacetanilide With Different Aromatic Aldehydes At Variety Method Of Reaction.

17) Mahida, J., & Patel, R. B. (2019). Application of Silica Supported Aluminium Hydroxide as a Low Cost Green Catalyst for the One Pot MCR Sythesis via Thermal Method. Journal of Drug Delivery and Therapeutics, 9(4-s), 43-47.

18) Mahida, J., & Patel, R. B. (2019). Application of Silica Supported Aluminium Hydroxide as a Low Cost Green Catalyst for the One Pot MCR Sythesis via Thermal Method. Journal of Drug Delivery and Therapeutics, 9(4-s), 43-47.

19) Mohareb, R. M., Abdallah, A. E. M., & Mohamed, A. A. (2018). Synthesis of novel thiophene, thiazole and coumarin derivatives based on benzimidazole nucleus and their cytotoxicity and toxicity evaluations. Chemical and Pharmaceutical Bulletin, 66(3), 309-318.

20) Brandão, P., Pineiro, M., & Pinho e Melo, T. M. (2019). Flow chemistry: Towards a more sustainable heterocyclic synthesis. European Journal of Organic Chemistry, 2019(43), 7188-7217.

21) Kolarević, A., Ilić, B. S., Anastassova, N., Mavrova, A. T., Yancheva, D., Kocić, G., & Šmelcerović, A. (2018). Benzimidazoles as novel deoxyribonuclease I inhibitors. Journal of cellular biochemistry, 119(11), 8937-8948.

22) Wang, Z., Deng, X., Xiong, S., Xiong, R., Liu, J., Zou, L., ... & Tang, G. (2018). Design, synthesis and biological evaluation of chrysin benzimidazole derivatives as potential anticancer agents. Natural product research, 32(24), 2900-2909.

23) Chaves, S., Resta, S., Rinaldo, F., Costa, M., Josselin, R., Gwizdala, K., ... & Santos, M. A. (2020). Design, synthesis, and in vitro evaluation of hydroxybenzimidazole-donepezil analogues as multitarget-directed ligands for the treatment of Alzheimer’s disease. Molecules, 25(4), 985.

24) Cicco, L., Dilauro, G., Perna, F. M., Vitale, P., & Capriati, V. (2021). Advances in deep eutectic solvents and water: applications in metal-and biocatalyzed processes, in the synthesis of APIs, and other biologically active compounds. Organic & Biomolecular Chemistry, 19(12), 2558-2577.

25) Fanjul-Mosteirín, N., & del Amo, V. (2021). Organocatalytic transformations in deep eutectic solvents: Green methodologies made greener. Tetrahedron, 84, 131967.

26) Xie, Q., Zheng, X., Li, L., Ma, L., Zhao, Q., Chang, S., & You, L. (2021). Effect of Curcumin Addition on the Properties of Biodegradable Pectin/Chitosan Films. Molecules, 26(8), 2152.

27) Delavault, A., Opochenska, O., Laneque, L., Soergel, H., Muhle-Goll, C., Ochsenreither, K., & Syldatk, C. (2021). Lipase-Catalyzed Production of Sorbitol Laurate in a “2-in-1” Deep Eutectic System: Factors Affecting the Synthesis and Scalability. Molecules, 26(9), 2759.

28) Queda, F., Calò, S., Gwizdala, K., Magalhães, J. D., Cardoso, S. M., Chaves, S., ... & Santos, M. A. (2021). Novel Donepezil–Arylsulfonamide Hybrids as Multitarget-Directed Ligands for Potential Treatment of Alzheimer’s Disease. Molecules, 26(6), 1658.

29) Hollenbach, R., Ochsenreither, K., & Syldatk, C. (2021). Parameters Influencing Lipase-Catalyzed Glycolipid Synthesis by (Trans-) Esterification Reaction.

30) synthesis & Analysis of some novel amine based heterocyclic compounds and its derivatives prepare by different catalyst concentration and time duration J MAHIDA IJSART 4 (2), 25